Protein Kinase A Effects of an Expressed PRKAR1A Mutation Associated with Aggressive Tumors
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چکیده
منابع مشابه
Mutation Associated with Aggressive Tumors PRKAR1A Protein Kinase A Effects of an Expressed
Most PRKAR1A tumorigenic mutations lead to nonsense mRNA that is decayed; tumor formation has been associated with an increase in type II protein kinase A (PKA) subunits. The IVS6+1G>T PRKAR1A mutation leads to a protein lacking exon 6 sequences [R1A#184-236 (R1A#6)]. We compared in vitro R1A#6 with wild-type (wt) R1A. We assessed PKA activity and subunit expression, phosphorylation of target m...
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Most PRKAR1A tumorigenic mutations lead to nonsense mRNA that is decayed; tumor formation has been associated with an increase in type II protein kinase A (PKA) subunits. The IVS6+1G>T PRKAR1A mutation leads to a protein lacking exon 6 sequences [R1 alpha Delta 184-236 (R1 alpha Delta 6)]. We compared in vitro R1 alpha Delta 6 with wild-type (wt) R1 alpha. We assessed PKA activity and subunit e...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2008
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-08-0064